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¡¡¡¡Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeverydayENGLISHTHISWILLBEDISPLAYEDONMULTILANGUAGEPAGEONLYOURCOMMITMENTTOPRIVACYAtourcompany,privacybeginswithtrust.In2001,MerckCo.,Inc.,Kenilworth,NJ,USA,whichhasatradenameofMSDoutsideoftheU.S.andCanada,establishedaPrivacyOfficetodevelopandoverseeaglobalprivacyprogramforouroperationsaroundtheworld.Ourprogramisbasedonfourprivacyvaluesthatprovidethefoundationforresponsibleengagement,interactionsanduseofinformationaboutpeople:Ourprivacyprogramisbuiltonaplatformoforganizationalaccountabilityforprivacy,stewardshipofthedataweusetooperateourbusiness,consistentglobalprivacypracticesandstandardsthatcarryonourtraditionofupholdinghighethicalstandardsacrossourbusinesspractices,andongoingoversighttoensurethatwecontinuetorespondtochangesinprivacyexpectationsastechnologyandourbusinesscontinuetoevolve.Formoreinformationaboutourprogram,pleaseseethe.OurApproachtoPrivacyTrustSincewebelievethattrustisacoreprivacyvalueandessentialtoourcorporatemissiontodiscover,developandprovideinnovativeproductsandservicesthatsaveandimprovelivesaroundtheworld,ourglobalprivacyprogramstrategyiscenteredontwoprimarygoalsthataimtodrivetrustinhowweengagewithpeopleandhowweaccess,useandtransferinformationaboutpeoplearoundtheworld:ConsistentGlobalStandardsSinceweestablishedourglobalprivacyprogramin2001,wehaveworkedtoimplementandupholdconsistentglobalprivacystandardstoprovideassuranceforhowwemanageourprivacyanddataprotectionobligationsacrosscountriesandregionsandtosupportourcertificationsunderthefollowingprivacyframeworksrecognizedbyregulators:EachofourcertificationsisbasedonourTransparencyWerecognizethatitcanbedifficultandoverwhelmingforpeopletounderstandallofthedifferentwaysthatinformationaboutthemcanbeobserved,sensed,collected,shared,used,analyzedandtransferred,soweuseavarietyofapproachestosupportourgoalofmakingourpracticestransparentbothtopeopleaboutwhomweprocessinformationaswellastheregulatorsandtheiragentswhoreviewourpractices.Keyexamplesinclude:TransparencyinourPrivacyProgramOurprivacynoticesareanimportantpartofourapproachtotransparencyinwhatwedowithpersonalinformation.QuestionsAboutPrivacyWritetousat:PrivacyOfficeUG4B-24351N.SumneytownPikeNorthWales,PA19454E-mail:Copyright2009-2018MerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.Kenilworth,NJ,USA.Allrightsreserved.ThiswebsiteismaintainedbyMerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.,Kenilworth,NJ,USA.ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:

¡¡¡¡AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..Inmanycountriesaroundtheworld,suchasCanada,UK,India,Brazil,andChina,ouremployeeshaveusedLIVEITasafoundationforbuildingalocalcultureofwell-being.InCanada,forexample,wedemonstratedimprovementsinbiometrics,fitnessandemotionalhealth,accompaniedbyfewerself-reportedabsences.LIVEIThaslaunchedto53,000employeesin40countries,representingover75percentoftheworkforce.AtMSD,wedefineacultureofwell-beingasadeliberateandresourcedefforttoestablishaworkforceculturethatpromoteshealth,wellnessandsafetyandisfocusedoncreatinghealthydailyhabits.Itembedshealthandsafetyintothedailyfabricoftheworkplace.Werecognizethatasustainablecultureofhealthrequiresstrongleadershipsupport,agrass-rootschampionnetwork(dedicatedandpassionateemployeevolunteers),aworkplaceenvironmentthatsupportshealthfuldecision-makingandastrongandlastingcommitmenttomarketthevalueofbeingwellwithinandacrosstheorganization.Therearemanybenefitstothisapproach.First,thehealthandwell-beingofourworkforcehaveadirectlinktooptimalemployeeperformance.Whetherworkisdoneattheofficeorathome,sickness,injuryandstresscanaffectaperson¡¯sabilitytoperformandcontributeeffectively.Second,thereisincreasingevidencethatahealthyandsafeworkforcecanprovideacompetitiveadvantageinthemarketplace.MSDhasanopportunitytobeanexampleforothercompaniesbysharinglearnings,bestpracticesandevidencethatsupportsthehypothesisthatgoodhealthissmartbusiness.Wealsobelievethataconstructiveapproachtoouremployees'healthandoverallwell-beinghelpstorecruitandretaintopanddiversetalent.Aspiringtoplayaleadershiprole,MSDisleveraginginternalassetsandexternalexpertisetopromotehealthandbuildacorporatecultureofhealth.BecauseatMSDwearetopromoteoptimalhealth,wemustleadbyexample.Wemustbehealthyourselvestodotheimportantworkofsavingandimprovingthelivesofothers.Ittakesmorethanhavingtherightmechanisms,standardsandtraininginplacetoensureanopen,ethicalbusinessenvironment.Weworkhardtomakesureweliveuptoourownhighstandards,everyday.LearnmoreWestrivetooperateopenlyandtransparentlyineverythingwedo.Becauseyourtrustinusdependsonit.Weworktoattractandretaindiversesuppliers¨Clargeandsmall¨Cinourmarketsaroundtheworld.Weworkcloselywiththisglobalnetworktoprovidethehighestlevelofservicetoourcustomersandachieveawin-winbusinessrelationship.

¡¡¡¡Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..

¡¡¡¡Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.

¡¡¡¡Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:ENGLISHTHISWILLBEDISPLAYEDONMULTILANGUAGEPAGEONLYOURCOMMITMENTTOPRIVACYAtourcompany,privacybeginswithtrust.In2001,MerckCo.,Inc.,Kenilworth,NJ,USA,whichhasatradenameofMSDoutsideoftheU.S.andCanada,establishedaPrivacyOfficetodevelopandoverseeaglobalprivacyprogramforouroperationsaroundtheworld.Ourprogramisbasedonfourprivacyvaluesthatprovidethefoundationforresponsibleengagement,interactionsanduseofinformationaboutpeople:Ourprivacyprogramisbuiltonaplatformoforganizationalaccountabilityforprivacy,stewardshipofthedataweusetooperateourbusiness,consistentglobalprivacypracticesandstandardsthatcarryonourtraditionofupholdinghighethicalstandardsacrossourbusinesspractices,andongoingoversighttoensurethatwecontinuetorespondtochangesinprivacyexpectationsastechnologyandourbusinesscontinuetoevolve.Formoreinformationaboutourprogram,pleaseseethe.OurApproachtoPrivacyTrustSincewebelievethattrustisacoreprivacyvalueandessentialtoourcorporatemissiontodiscover,developandprovideinnovativeproductsandservicesthatsaveandimprovelivesaroundtheworld,ourglobalprivacyprogramstrategyiscenteredontwoprimarygoalsthataimtodrivetrustinhowweengagewithpeopleandhowweaccess,useandtransferinformationaboutpeoplearoundtheworld:ConsistentGlobalStandardsSinceweestablishedourglobalprivacyprogramin2001,wehaveworkedtoimplementandupholdconsistentglobalprivacystandardstoprovideassuranceforhowwemanageourprivacyanddataprotectionobligationsacrosscountriesandregionsandtosupportourcertificationsunderthefollowingprivacyframeworksrecognizedbyregulators:EachofourcertificationsisbasedonourTransparencyWerecognizethatitcanbedifficultandoverwhelmingforpeopletounderstandallofthedifferentwaysthatinformationaboutthemcanbeobserved,sensed,collected,shared,used,analyzedandtransferred,soweuseavarietyofapproachestosupportourgoalofmakingourpracticestransparentbothtopeopleaboutwhomweprocessinformationaswellastheregulatorsandtheiragentswhoreviewourpractices.Keyexamplesinclude:TransparencyinourPrivacyProgramOurprivacynoticesareanimportantpartofourapproachtotransparencyinwhatwedowithpersonalinformation.QuestionsAboutPrivacyWritetousat:PrivacyOfficeUG4B-24351N.SumneytownPikeNorthWales,PA19454E-mail:Copyright2009-2018MerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.Kenilworth,NJ,USA.Allrightsreserved.ThiswebsiteismaintainedbyMerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.,Kenilworth,NJ,USA.Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:

¡¡¡¡Ittakesmorethanhavingtherightmechanisms,standardsandtraininginplacetoensureanopen,ethicalbusinessenvironment.Weworkhardtomakesureweliveuptoourownhighstandards,everyday.LearnmoreWestrivetooperateopenlyandtransparentlyineverythingwedo.Becauseyourtrustinusdependsonit.Weworktoattractandretaindiversesuppliers¨Clargeandsmall¨Cinourmarketsaroundtheworld.Weworkcloselywiththisglobalnetworktoprovidethehighestlevelofservicetoourcustomersandachieveawin-winbusinessrelationship.DescriptionMSDisaninnovative,globalhealthcareleaderthatiscommittedtoimprovinghealthandwell-beingaroundtheworld.Ourcoreproductcategoriesincludediabetes,cancer,vaccinesandhospitalacutecare.Wecontinuetofocusourresearchonconditionsthatrepresentsomeoftoday¡¯smostsignificanthealthchallenges¨Clikecancer,HIV,HPV,hepatitisC,cardio-metabolicdisease,antibiotic-resistantinfectionandAlzheimer'sdisease,andweareonthefrontlinesinthefightagainstemergingglobalpandemics,suchasebola.Wealsodevoteextensivetimeandenergytoincreasingaccesstomedicinesandvaccinesthroughfar-reachingprogramsthatdonateanddeliverourproductstothepeoplewhoneedthem.AtMSD,we'reapplyingourglobalreach,financialstrengthandscientificexcellencetodomoreofwhatwe'repassionateabout:improvinghealthandimprovinglives.AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..

¡¡¡¡Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.Inmanycountriesaroundtheworld,suchasCanada,UK,India,Brazil,andChina,ouremployeeshaveusedLIVEITasafoundationforbuildingalocalcultureofwell-being.InCanada,forexample,wedemonstratedimprovementsinbiometrics,fitnessandemotionalhealth,accompaniedbyfewerself-reportedabsences.LIVEIThaslaunchedto53,000employeesin40countries,representingover75percentoftheworkforce.AtMSD,wedefineacultureofwell-beingasadeliberateandresourcedefforttoestablishaworkforceculturethatpromoteshealth,wellnessandsafetyandisfocusedoncreatinghealthydailyhabits.Itembedshealthandsafetyintothedailyfabricoftheworkplace.Werecognizethatasustainablecultureofhealthrequiresstrongleadershipsupport,agrass-rootschampionnetwork(dedicatedandpassionateemployeevolunteers),aworkplaceenvironmentthatsupportshealthfuldecision-makingandastrongandlastingcommitmenttomarketthevalueofbeingwellwithinandacrosstheorganization.Therearemanybenefitstothisapproach.First,thehealthandwell-beingofourworkforcehaveadirectlinktooptimalemployeeperformance.Whetherworkisdoneattheofficeorathome,sickness,injuryandstresscanaffectaperson¡¯sabilitytoperformandcontributeeffectively.Second,thereisincreasingevidencethatahealthyandsafeworkforcecanprovideacompetitiveadvantageinthemarketplace.MSDhasanopportunitytobeanexampleforothercompaniesbysharinglearnings,bestpracticesandevidencethatsupportsthehypothesisthatgoodhealthissmartbusiness.Wealsobelievethataconstructiveapproachtoouremployees'healthandoverallwell-beinghelpstorecruitandretaintopanddiversetalent.Aspiringtoplayaleadershiprole,MSDisleveraginginternalassetsandexternalexpertisetopromotehealthandbuildacorporatecultureofhealth.BecauseatMSDwearetopromoteoptimalhealth,wemustleadbyexample.Wemustbehealthyourselvestodotheimportantworkofsavingandimprovingthelivesofothers.Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:

¡¡¡¡ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:Oursuppliersshouldreflectthepeopleweareinbusinesstoserve...ourcustomers.AtMSD,webelievethathavingadiversesupplierbasehelpsusbetterunderstandandanticipatetheneedsofthepeopleweserve.Thatiswhywecastawidenetinsearchoftalent,seekingqualifiedsuppliersfromallsegmentsoftheglobalcommunity.OursupplierdiversityprogramincludeslargeandsmallHUBZone,minority,women,veteran,andlesbian-andgay-ownedbusinessenterprisesInterestedinbecominganMSDsupplierHere'swhatwe'llexpectfromyou:Weholdoursupplierstothesamestandardstowhichweholdourownemployees.Weexpectoursuppliersto:Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.

¡¡¡¡ENGLISHTHISWILLBEDISPLAYEDONMULTILANGUAGEPAGEONLYOURCOMMITMENTTOPRIVACYAtourcompany,privacybeginswithtrust.In2001,MerckCo.,Inc.,Kenilworth,NJ,USA,whichhasatradenameofMSDoutsideoftheU.S.andCanada,establishedaPrivacyOfficetodevelopandoverseeaglobalprivacyprogramforouroperationsaroundtheworld.Ourprogramisbasedonfourprivacyvaluesthatprovidethefoundationforresponsibleengagement,interactionsanduseofinformationaboutpeople:Ourprivacyprogramisbuiltonaplatformoforganizationalaccountabilityforprivacy,stewardshipofthedataweusetooperateourbusiness,consistentglobalprivacypracticesandstandardsthatcarryonourtraditionofupholdinghighethicalstandardsacrossourbusinesspractices,andongoingoversighttoensurethatwecontinuetorespondtochangesinprivacyexpectationsastechnologyandourbusinesscontinuetoevolve.Formoreinformationaboutourprogram,pleaseseethe.OurApproachtoPrivacyTrustSincewebelievethattrustisacoreprivacyvalueandessentialtoourcorporatemissiontodiscover,developandprovideinnovativeproductsandservicesthatsaveandimprovelivesaroundtheworld,ourglobalprivacyprogramstrategyiscenteredontwoprimarygoalsthataimtodrivetrustinhowweengagewithpeopleandhowweaccess,useandtransferinformationaboutpeoplearoundtheworld:ConsistentGlobalStandardsSinceweestablishedourglobalprivacyprogramin2001,wehaveworkedtoimplementandupholdconsistentglobalprivacystandardstoprovideassuranceforhowwemanageourprivacyanddataprotectionobligationsacrosscountriesandregionsandtosupportourcertificationsunderthefollowingprivacyframeworksrecognizedbyregulators:EachofourcertificationsisbasedonourTransparencyWerecognizethatitcanbedifficultandoverwhelmingforpeopletounderstandallofthedifferentwaysthatinformationaboutthemcanbeobserved,sensed,collected,shared,used,analyzedandtransferred,soweuseavarietyofapproachestosupportourgoalofmakingourpracticestransparentbothtopeopleaboutwhomweprocessinformationaswellastheregulatorsandtheiragentswhoreviewourpractices.Keyexamplesinclude:TransparencyinourPrivacyProgramOurprivacynoticesareanimportantpartofourapproachtotransparencyinwhatwedowithpersonalinformation.QuestionsAboutPrivacyWritetousat:PrivacyOfficeUG4B-24351N.SumneytownPikeNorthWales,PA19454E-mail:Copyright2009-2018MerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.Kenilworth,NJ,USA.Allrightsreserved.ThiswebsiteismaintainedbyMerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.,Kenilworth,NJ,USA.AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..ENGLISHTHISWILLBEDISPLAYEDONMULTILANGUAGEPAGEONLYOURCOMMITMENTTOPRIVACYAtourcompany,privacybeginswithtrust.In2001,MerckCo.,Inc.,Kenilworth,NJ,USA,whichhasatradenameofMSDoutsideoftheU.S.andCanada,establishedaPrivacyOfficetodevelopandoverseeaglobalprivacyprogramforouroperationsaroundtheworld.Ourprogramisbasedonfourprivacyvaluesthatprovidethefoundationforresponsibleengagement,interactionsanduseofinformationaboutpeople:Ourprivacyprogramisbuiltonaplatformoforganizationalaccountabilityforprivacy,stewardshipofthedataweusetooperateourbusiness,consistentglobalprivacypracticesandstandardsthatcarryonourtraditionofupholdinghighethicalstandardsacrossourbusinesspractices,andongoingoversighttoensurethatwecontinuetorespondtochangesinprivacyexpectationsastechnologyandourbusinesscontinuetoevolve.Formoreinformationaboutourprogram,pleaseseethe.OurApproachtoPrivacyTrustSincewebelievethattrustisacoreprivacyvalueandessentialtoourcorporatemissiontodiscover,developandprovideinnovativeproductsandservicesthatsaveandimprovelivesaroundtheworld,ourglobalprivacyprogramstrategyiscenteredontwoprimarygoalsthataimtodrivetrustinhowweengagewithpeopleandhowweaccess,useandtransferinformationaboutpeoplearoundtheworld:ConsistentGlobalStandardsSinceweestablishedourglobalprivacyprogramin2001,wehaveworkedtoimplementandupholdconsistentglobalprivacystandardstoprovideassuranceforhowwemanageourprivacyanddataprotectionobligationsacrosscountriesandregionsandtosupportourcertificationsunderthefollowingprivacyframeworksrecognizedbyregulators:EachofourcertificationsisbasedonourTransparencyWerecognizethatitcanbedifficultandoverwhelmingforpeopletounderstandallofthedifferentwaysthatinformationaboutthemcanbeobserved,sensed,collected,shared,used,analyzedandtransferred,soweuseavarietyofapproachestosupportourgoalofmakingourpracticestransparentbothtopeopleaboutwhomweprocessinformationaswellastheregulatorsandtheiragentswhoreviewourpractices.Keyexamplesinclude:TransparencyinourPrivacyProgramOurprivacynoticesareanimportantpartofourapproachtotransparencyinwhatwedowithpersonalinformation.QuestionsAboutPrivacyWritetousat:PrivacyOfficeUG4B-24351N.SumneytownPikeNorthWales,PA19454E-mail:Copyright2009-2018MerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.Kenilworth,NJ,USA.Allrightsreserved.ThiswebsiteismaintainedbyMerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.,Kenilworth,NJ,USA.

¡¡¡¡Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeveryday

¡¡¡¡ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeveryday

¡¡¡¡Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.ENGLISHTHISWILLBEDISPLAYEDONMULTILANGUAGEPAGEONLYOURCOMMITMENTTOPRIVACYAtourcompany,privacybeginswithtrust.In2001,MerckCo.,Inc.,Kenilworth,NJ,USA,whichhasatradenameofMSDoutsideoftheU.S.andCanada,establishedaPrivacyOfficetodevelopandoverseeaglobalprivacyprogramforouroperationsaroundtheworld.Ourprogramisbasedonfourprivacyvaluesthatprovidethefoundationforresponsibleengagement,interactionsanduseofinformationaboutpeople:Ourprivacyprogramisbuiltonaplatformoforganizationalaccountabilityforprivacy,stewardshipofthedataweusetooperateourbusiness,consistentglobalprivacypracticesandstandardsthatcarryonourtraditionofupholdinghighethicalstandardsacrossourbusinesspractices,andongoingoversighttoensurethatwecontinuetorespondtochangesinprivacyexpectationsastechnologyandourbusinesscontinuetoevolve.Formoreinformationaboutourprogram,pleaseseethe.OurApproachtoPrivacyTrustSincewebelievethattrustisacoreprivacyvalueandessentialtoourcorporatemissiontodiscover,developandprovideinnovativeproductsandservicesthatsaveandimprovelivesaroundtheworld,ourglobalprivacyprogramstrategyiscenteredontwoprimarygoalsthataimtodrivetrustinhowweengagewithpeopleandhowweaccess,useandtransferinformationaboutpeoplearoundtheworld:ConsistentGlobalStandardsSinceweestablishedourglobalprivacyprogramin2001,wehaveworkedtoimplementandupholdconsistentglobalprivacystandardstoprovideassuranceforhowwemanageourprivacyanddataprotectionobligationsacrosscountriesandregionsandtosupportourcertificationsunderthefollowingprivacyframeworksrecognizedbyregulators:EachofourcertificationsisbasedonourTransparencyWerecognizethatitcanbedifficultandoverwhelmingforpeopletounderstandallofthedifferentwaysthatinformationaboutthemcanbeobserved,sensed,collected,shared,used,analyzedandtransferred,soweuseavarietyofapproachestosupportourgoalofmakingourpracticestransparentbothtopeopleaboutwhomweprocessinformationaswellastheregulatorsandtheiragentswhoreviewourpractices.Keyexamplesinclude:TransparencyinourPrivacyProgramOurprivacynoticesareanimportantpartofourapproachtotransparencyinwhatwedowithpersonalinformation.QuestionsAboutPrivacyWritetousat:PrivacyOfficeUG4B-24351N.SumneytownPikeNorthWales,PA19454E-mail:Copyright2009-2018MerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.Kenilworth,NJ,USA.Allrightsreserved.ThiswebsiteismaintainedbyMerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.,Kenilworth,NJ,USA.Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeveryday

¡¡¡¡Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.Inmanycountriesaroundtheworld,suchasCanada,UK,India,Brazil,andChina,ouremployeeshaveusedLIVEITasafoundationforbuildingalocalcultureofwell-being.InCanada,forexample,wedemonstratedimprovementsinbiometrics,fitnessandemotionalhealth,accompaniedbyfewerself-reportedabsences.LIVEIThaslaunchedto53,000employeesin40countries,representingover75percentoftheworkforce.AtMSD,wedefineacultureofwell-beingasadeliberateandresourcedefforttoestablishaworkforceculturethatpromoteshealth,wellnessandsafetyandisfocusedoncreatinghealthydailyhabits.Itembedshealthandsafetyintothedailyfabricoftheworkplace.Werecognizethatasustainablecultureofhealthrequiresstrongleadershipsupport,agrass-rootschampionnetwork(dedicatedandpassionateemployeevolunteers),aworkplaceenvironmentthatsupportshealthfuldecision-makingandastrongandlastingcommitmenttomarketthevalueofbeingwellwithinandacrosstheorganization.Therearemanybenefitstothisapproach.First,thehealthandwell-beingofourworkforcehaveadirectlinktooptimalemployeeperformance.Whetherworkisdoneattheofficeorathome,sickness,injuryandstresscanaffectaperson¡¯sabilitytoperformandcontributeeffectively.Second,thereisincreasingevidencethatahealthyandsafeworkforcecanprovideacompetitiveadvantageinthemarketplace.MSDhasanopportunitytobeanexampleforothercompaniesbysharinglearnings,bestpracticesandevidencethatsupportsthehypothesisthatgoodhealthissmartbusiness.Wealsobelievethataconstructiveapproachtoouremployees'healthandoverallwell-beinghelpstorecruitandretaintopanddiversetalent.Aspiringtoplayaleadershiprole,MSDisleveraginginternalassetsandexternalexpertisetopromotehealthandbuildacorporatecultureofhealth.BecauseatMSDwearetopromoteoptimalhealth,wemustleadbyexample.Wemustbehealthyourselvestodotheimportantworkofsavingandimprovingthelivesofothers.Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.

¡¡¡¡Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeverydayAstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:

¡¡¡¡Ittakesmorethanhavingtherightmechanisms,standardsandtraininginplacetoensureanopen,ethicalbusinessenvironment.Weworkhardtomakesureweliveuptoourownhighstandards,everyday.LearnmoreWestrivetooperateopenlyandtransparentlyineverythingwedo.Becauseyourtrustinusdependsonit.Weworktoattractandretaindiversesuppliers¨Clargeandsmall¨Cinourmarketsaroundtheworld.Weworkcloselywiththisglobalnetworktoprovidethehighestlevelofservicetoourcustomersandachieveawin-winbusinessrelationship.AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..Oursuppliersshouldreflectthepeopleweareinbusinesstoserve...ourcustomers.AtMSD,webelievethathavingadiversesupplierbasehelpsusbetterunderstandandanticipatetheneedsofthepeopleweserve.Thatiswhywecastawidenetinsearchoftalent,seekingqualifiedsuppliersfromallsegmentsoftheglobalcommunity.OursupplierdiversityprogramincludeslargeandsmallHUBZone,minority,women,veteran,andlesbian-andgay-ownedbusinessenterprisesInterestedinbecominganMSDsupplierHere'swhatwe'llexpectfromyou:Weholdoursupplierstothesamestandardstowhichweholdourownemployees.Weexpectoursuppliersto:

¡¡¡¡Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.

¡¡¡¡Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.DescriptionMSDisaninnovative,globalhealthcareleaderthatiscommittedtoimprovinghealthandwell-beingaroundtheworld.Ourcoreproductcategoriesincludediabetes,cancer,vaccinesandhospitalacutecare.Wecontinuetofocusourresearchonconditionsthatrepresentsomeoftoday¡¯smostsignificanthealthchallenges¨Clikecancer,HIV,HPV,hepatitisC,cardio-metabolicdisease,antibiotic-resistantinfectionandAlzheimer'sdisease,andweareonthefrontlinesinthefightagainstemergingglobalpandemics,suchasebola.Wealsodevoteextensivetimeandenergytoincreasingaccesstomedicinesandvaccinesthroughfar-reachingprogramsthatdonateanddeliverourproductstothepeoplewhoneedthem.AtMSD,we'reapplyingourglobalreach,financialstrengthandscientificexcellencetodomoreofwhatwe'repassionateabout:improvinghealthandimprovinglives.Inmanycountriesaroundtheworld,suchasCanada,UK,India,Brazil,andChina,ouremployeeshaveusedLIVEITasafoundationforbuildingalocalcultureofwell-being.InCanada,forexample,wedemonstratedimprovementsinbiometrics,fitnessandemotionalhealth,accompaniedbyfewerself-reportedabsences.LIVEIThaslaunchedto53,000employeesin40countries,representingover75percentoftheworkforce.AtMSD,wedefineacultureofwell-beingasadeliberateandresourcedefforttoestablishaworkforceculturethatpromoteshealth,wellnessandsafetyandisfocusedoncreatinghealthydailyhabits.Itembedshealthandsafetyintothedailyfabricoftheworkplace.Werecognizethatasustainablecultureofhealthrequiresstrongleadershipsupport,agrass-rootschampionnetwork(dedicatedandpassionateemployeevolunteers),aworkplaceenvironmentthatsupportshealthfuldecision-makingandastrongandlastingcommitmenttomarketthevalueofbeingwellwithinandacrosstheorganization.Therearemanybenefitstothisapproach.First,thehealthandwell-beingofourworkforcehaveadirectlinktooptimalemployeeperformance.Whetherworkisdoneattheofficeorathome,sickness,injuryandstresscanaffectaperson¡¯sabilitytoperformandcontributeeffectively.Second,thereisincreasingevidencethatahealthyandsafeworkforcecanprovideacompetitiveadvantageinthemarketplace.MSDhasanopportunitytobeanexampleforothercompaniesbysharinglearnings,bestpracticesandevidencethatsupportsthehypothesisthatgoodhealthissmartbusiness.Wealsobelievethataconstructiveapproachtoouremployees'healthandoverallwell-beinghelpstorecruitandretaintopanddiversetalent.Aspiringtoplayaleadershiprole,MSDisleveraginginternalassetsandexternalexpertisetopromotehealthandbuildacorporatecultureofhealth.BecauseatMSDwearetopromoteoptimalhealth,wemustleadbyexample.Wemustbehealthyourselvestodotheimportantworkofsavingandimprovingthelivesofothers.

¡¡¡¡Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.DescriptionMSDisaninnovative,globalhealthcareleaderthatiscommittedtoimprovinghealthandwell-beingaroundtheworld.Ourcoreproductcategoriesincludediabetes,cancer,vaccinesandhospitalacutecare.Wecontinuetofocusourresearchonconditionsthatrepresentsomeoftoday¡¯smostsignificanthealthchallenges¨Clikecancer,HIV,HPV,hepatitisC,cardio-metabolicdisease,antibiotic-resistantinfectionandAlzheimer'sdisease,andweareonthefrontlinesinthefightagainstemergingglobalpandemics,suchasebola.Wealsodevoteextensivetimeandenergytoincreasingaccesstomedicinesandvaccinesthroughfar-reachingprogramsthatdonateanddeliverourproductstothepeoplewhoneedthem.AtMSD,we'reapplyingourglobalreach,financialstrengthandscientificexcellencetodomoreofwhatwe'repassionateabout:improvinghealthandimprovinglives.Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:

¡¡¡¡Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeverydayOurvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:

¡¡¡¡AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..

¡¡¡¡Ittakesmorethanhavingtherightmechanisms,standardsandtraininginplacetoensureanopen,ethicalbusinessenvironment.Weworkhardtomakesureweliveuptoourownhighstandards,everyday.LearnmoreWestrivetooperateopenlyandtransparentlyineverythingwedo.Becauseyourtrustinusdependsonit.Weworktoattractandretaindiversesuppliers¨Clargeandsmall¨Cinourmarketsaroundtheworld.Weworkcloselywiththisglobalnetworktoprovidethehighestlevelofservicetoourcustomersandachieveawin-winbusinessrelationship.Oursuppliersshouldreflectthepeopleweareinbusinesstoserve...ourcustomers.AtMSD,webelievethathavingadiversesupplierbasehelpsusbetterunderstandandanticipatetheneedsofthepeopleweserve.Thatiswhywecastawidenetinsearchoftalent,seekingqualifiedsuppliersfromallsegmentsoftheglobalcommunity.OursupplierdiversityprogramincludeslargeandsmallHUBZone,minority,women,veteran,andlesbian-andgay-ownedbusinessenterprisesInterestedinbecominganMSDsupplierHere'swhatwe'llexpectfromyou:Weholdoursupplierstothesamestandardstowhichweholdourownemployees.Weexpectoursuppliersto:Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeveryday

¡¡¡¡Oursuppliersshouldreflectthepeopleweareinbusinesstoserve...ourcustomers.AtMSD,webelievethathavingadiversesupplierbasehelpsusbetterunderstandandanticipatetheneedsofthepeopleweserve.Thatiswhywecastawidenetinsearchoftalent,seekingqualifiedsuppliersfromallsegmentsoftheglobalcommunity.OursupplierdiversityprogramincludeslargeandsmallHUBZone,minority,women,veteran,andlesbian-andgay-ownedbusinessenterprisesInterestedinbecominganMSDsupplierHere'swhatwe'llexpectfromyou:Weholdoursupplierstothesamestandardstowhichweholdourownemployees.Weexpectoursuppliersto:Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:ENGLISHTHISWILLBEDISPLAYEDONMULTILANGUAGEPAGEONLYOURCOMMITMENTTOPRIVACYAtourcompany,privacybeginswithtrust.In2001,MerckCo.,Inc.,Kenilworth,NJ,USA,whichhasatradenameofMSDoutsideoftheU.S.andCanada,establishedaPrivacyOfficetodevelopandoverseeaglobalprivacyprogramforouroperationsaroundtheworld.Ourprogramisbasedonfourprivacyvaluesthatprovidethefoundationforresponsibleengagement,interactionsanduseofinformationaboutpeople:Ourprivacyprogramisbuiltonaplatformoforganizationalaccountabilityforprivacy,stewardshipofthedataweusetooperateourbusiness,consistentglobalprivacypracticesandstandardsthatcarryonourtraditionofupholdinghighethicalstandardsacrossourbusinesspractices,andongoingoversighttoensurethatwecontinuetorespondtochangesinprivacyexpectationsastechnologyandourbusinesscontinuetoevolve.Formoreinformationaboutourprogram,pleaseseethe.OurApproachtoPrivacyTrustSincewebelievethattrustisacoreprivacyvalueandessentialtoourcorporatemissiontodiscover,developandprovideinnovativeproductsandservicesthatsaveandimprovelivesaroundtheworld,ourglobalprivacyprogramstrategyiscenteredontwoprimarygoalsthataimtodrivetrustinhowweengagewithpeopleandhowweaccess,useandtransferinformationaboutpeoplearoundtheworld:ConsistentGlobalStandardsSinceweestablishedourglobalprivacyprogramin2001,wehaveworkedtoimplementandupholdconsistentglobalprivacystandardstoprovideassuranceforhowwemanageourprivacyanddataprotectionobligationsacrosscountriesandregionsandtosupportourcertificationsunderthefollowingprivacyframeworksrecognizedbyregulators:EachofourcertificationsisbasedonourTransparencyWerecognizethatitcanbedifficultandoverwhelmingforpeopletounderstandallofthedifferentwaysthatinformationaboutthemcanbeobserved,sensed,collected,shared,used,analyzedandtransferred,soweuseavarietyofapproachestosupportourgoalofmakingourpracticestransparentbothtopeopleaboutwhomweprocessinformationaswellastheregulatorsandtheiragentswhoreviewourpractices.Keyexamplesinclude:TransparencyinourPrivacyProgramOurprivacynoticesareanimportantpartofourapproachtotransparencyinwhatwedowithpersonalinformation.QuestionsAboutPrivacyWritetousat:PrivacyOfficeUG4B-24351N.SumneytownPikeNorthWales,PA19454E-mail:Copyright2009-2018MerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.Kenilworth,NJ,USA.Allrightsreserved.ThiswebsiteismaintainedbyMerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.,Kenilworth,NJ,USA.

¡¡¡¡ENGLISHTHISWILLBEDISPLAYEDONMULTILANGUAGEPAGEONLYOURCOMMITMENTTOPRIVACYAtourcompany,privacybeginswithtrust.In2001,MerckCo.,Inc.,Kenilworth,NJ,USA,whichhasatradenameofMSDoutsideoftheU.S.andCanada,establishedaPrivacyOfficetodevelopandoverseeaglobalprivacyprogramforouroperationsaroundtheworld.Ourprogramisbasedonfourprivacyvaluesthatprovidethefoundationforresponsibleengagement,interactionsanduseofinformationaboutpeople:Ourprivacyprogramisbuiltonaplatformoforganizationalaccountabilityforprivacy,stewardshipofthedataweusetooperateourbusiness,consistentglobalprivacypracticesandstandardsthatcarryonourtraditionofupholdinghighethicalstandardsacrossourbusinesspractices,andongoingoversighttoensurethatwecontinuetorespondtochangesinprivacyexpectationsastechnologyandourbusinesscontinuetoevolve.Formoreinformationaboutourprogram,pleaseseethe.OurApproachtoPrivacyTrustSincewebelievethattrustisacoreprivacyvalueandessentialtoourcorporatemissiontodiscover,developandprovideinnovativeproductsandservicesthatsaveandimprovelivesaroundtheworld,ourglobalprivacyprogramstrategyiscenteredontwoprimarygoalsthataimtodrivetrustinhowweengagewithpeopleandhowweaccess,useandtransferinformationaboutpeoplearoundtheworld:ConsistentGlobalStandardsSinceweestablishedourglobalprivacyprogramin2001,wehaveworkedtoimplementandupholdconsistentglobalprivacystandardstoprovideassuranceforhowwemanageourprivacyanddataprotectionobligationsacrosscountriesandregionsandtosupportourcertificationsunderthefollowingprivacyframeworksrecognizedbyregulators:EachofourcertificationsisbasedonourTransparencyWerecognizethatitcanbedifficultandoverwhelmingforpeopletounderstandallofthedifferentwaysthatinformationaboutthemcanbeobserved,sensed,collected,shared,used,analyzedandtransferred,soweuseavarietyofapproachestosupportourgoalofmakingourpracticestransparentbothtopeopleaboutwhomweprocessinformationaswellastheregulatorsandtheiragentswhoreviewourpractices.Keyexamplesinclude:TransparencyinourPrivacyProgramOurprivacynoticesareanimportantpartofourapproachtotransparencyinwhatwedowithpersonalinformation.QuestionsAboutPrivacyWritetousat:PrivacyOfficeUG4B-24351N.SumneytownPikeNorthWales,PA19454E-mail:Copyright2009-2018MerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.Kenilworth,NJ,USA.Allrightsreserved.ThiswebsiteismaintainedbyMerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.,Kenilworth,NJ,USA.Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..

¡¡¡¡Oursuppliersshouldreflectthepeopleweareinbusinesstoserve...ourcustomers.AtMSD,webelievethathavingadiversesupplierbasehelpsusbetterunderstandandanticipatetheneedsofthepeopleweserve.Thatiswhywecastawidenetinsearchoftalent,seekingqualifiedsuppliersfromallsegmentsoftheglobalcommunity.OursupplierdiversityprogramincludeslargeandsmallHUBZone,minority,women,veteran,andlesbian-andgay-ownedbusinessenterprisesInterestedinbecominganMSDsupplierHere'swhatwe'llexpectfromyou:Weholdoursupplierstothesamestandardstowhichweholdourownemployees.Weexpectoursuppliersto:ENGLISHTHISWILLBEDISPLAYEDONMULTILANGUAGEPAGEONLYOURCOMMITMENTTOPRIVACYAtourcompany,privacybeginswithtrust.In2001,MerckCo.,Inc.,Kenilworth,NJ,USA,whichhasatradenameofMSDoutsideoftheU.S.andCanada,establishedaPrivacyOfficetodevelopandoverseeaglobalprivacyprogramforouroperationsaroundtheworld.Ourprogramisbasedonfourprivacyvaluesthatprovidethefoundationforresponsibleengagement,interactionsanduseofinformationaboutpeople:Ourprivacyprogramisbuiltonaplatformoforganizationalaccountabilityforprivacy,stewardshipofthedataweusetooperateourbusiness,consistentglobalprivacypracticesandstandardsthatcarryonourtraditionofupholdinghighethicalstandardsacrossourbusinesspractices,andongoingoversighttoensurethatwecontinuetorespondtochangesinprivacyexpectationsastechnologyandourbusinesscontinuetoevolve.Formoreinformationaboutourprogram,pleaseseethe.OurApproachtoPrivacyTrustSincewebelievethattrustisacoreprivacyvalueandessentialtoourcorporatemissiontodiscover,developandprovideinnovativeproductsandservicesthatsaveandimprovelivesaroundtheworld,ourglobalprivacyprogramstrategyiscenteredontwoprimarygoalsthataimtodrivetrustinhowweengagewithpeopleandhowweaccess,useandtransferinformationaboutpeoplearoundtheworld:ConsistentGlobalStandardsSinceweestablishedourglobalprivacyprogramin2001,wehaveworkedtoimplementandupholdconsistentglobalprivacystandardstoprovideassuranceforhowwemanageourprivacyanddataprotectionobligationsacrosscountriesandregionsandtosupportourcertificationsunderthefollowingprivacyframeworksrecognizedbyregulators:EachofourcertificationsisbasedonourTransparencyWerecognizethatitcanbedifficultandoverwhelmingforpeopletounderstandallofthedifferentwaysthatinformationaboutthemcanbeobserved,sensed,collected,shared,used,analyzedandtransferred,soweuseavarietyofapproachestosupportourgoalofmakingourpracticestransparentbothtopeopleaboutwhomweprocessinformationaswellastheregulatorsandtheiragentswhoreviewourpractices.Keyexamplesinclude:TransparencyinourPrivacyProgramOurprivacynoticesareanimportantpartofourapproachtotransparencyinwhatwedowithpersonalinformation.QuestionsAboutPrivacyWritetousat:PrivacyOfficeUG4B-24351N.SumneytownPikeNorthWales,PA19454E-mail:Copyright2009-2018MerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.Kenilworth,NJ,USA.Allrightsreserved.ThiswebsiteismaintainedbyMerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.,Kenilworth,NJ,USA.ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:

¡¡¡¡AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..Ittakesmorethanhavingtherightmechanisms,standardsandtraininginplacetoensureanopen,ethicalbusinessenvironment.Weworkhardtomakesureweliveuptoourownhighstandards,everyday.LearnmoreWestrivetooperateopenlyandtransparentlyineverythingwedo.Becauseyourtrustinusdependsonit.Weworktoattractandretaindiversesuppliers¨Clargeandsmall¨Cinourmarketsaroundtheworld.Weworkcloselywiththisglobalnetworktoprovidethehighestlevelofservicetoourcustomersandachieveawin-winbusinessrelationship.Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeveryday

¡¡¡¡Ittakesmorethanhavingtherightmechanisms,standardsandtraininginplacetoensureanopen,ethicalbusinessenvironment.Weworkhardtomakesureweliveuptoourownhighstandards,everyday.LearnmoreWestrivetooperateopenlyandtransparentlyineverythingwedo.Becauseyourtrustinusdependsonit.Weworktoattractandretaindiversesuppliers¨Clargeandsmall¨Cinourmarketsaroundtheworld.Weworkcloselywiththisglobalnetworktoprovidethehighestlevelofservicetoourcustomersandachieveawin-winbusinessrelationship.ENGLISHTHISWILLBEDISPLAYEDONMULTILANGUAGEPAGEONLYOURCOMMITMENTTOPRIVACYAtourcompany,privacybeginswithtrust.In2001,MerckCo.,Inc.,Kenilworth,NJ,USA,whichhasatradenameofMSDoutsideoftheU.S.andCanada,establishedaPrivacyOfficetodevelopandoverseeaglobalprivacyprogramforouroperationsaroundtheworld.Ourprogramisbasedonfourprivacyvaluesthatprovidethefoundationforresponsibleengagement,interactionsanduseofinformationaboutpeople:Ourprivacyprogramisbuiltonaplatformoforganizationalaccountabilityforprivacy,stewardshipofthedataweusetooperateourbusiness,consistentglobalprivacypracticesandstandardsthatcarryonourtraditionofupholdinghighethicalstandardsacrossourbusinesspractices,andongoingoversighttoensurethatwecontinuetorespondtochangesinprivacyexpectationsastechnologyandourbusinesscontinuetoevolve.Formoreinformationaboutourprogram,pleaseseethe.OurApproachtoPrivacyTrustSincewebelievethattrustisacoreprivacyvalueandessentialtoourcorporatemissiontodiscover,developandprovideinnovativeproductsandservicesthatsaveandimprovelivesaroundtheworld,ourglobalprivacyprogramstrategyiscenteredontwoprimarygoalsthataimtodrivetrustinhowweengagewithpeopleandhowweaccess,useandtransferinformationaboutpeoplearoundtheworld:ConsistentGlobalStandardsSinceweestablishedourglobalprivacyprogramin2001,wehaveworkedtoimplementandupholdconsistentglobalprivacystandardstoprovideassuranceforhowwemanageourprivacyanddataprotectionobligationsacrosscountriesandregionsandtosupportourcertificationsunderthefollowingprivacyframeworksrecognizedbyregulators:EachofourcertificationsisbasedonourTransparencyWerecognizethatitcanbedifficultandoverwhelmingforpeopletounderstandallofthedifferentwaysthatinformationaboutthemcanbeobserved,sensed,collected,shared,used,analyzedandtransferred,soweuseavarietyofapproachestosupportourgoalofmakingourpracticestransparentbothtopeopleaboutwhomweprocessinformationaswellastheregulatorsandtheiragentswhoreviewourpractices.Keyexamplesinclude:TransparencyinourPrivacyProgramOurprivacynoticesareanimportantpartofourapproachtotransparencyinwhatwedowithpersonalinformation.QuestionsAboutPrivacyWritetousat:PrivacyOfficeUG4B-24351N.SumneytownPikeNorthWales,PA19454E-mail:Copyright2009-2018MerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.Kenilworth,NJ,USA.Allrightsreserved.ThiswebsiteismaintainedbyMerckSharpDohmeCorp.,asubsidiaryofMerckCo.,Inc.,Kenilworth,NJ,USA.Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.

¡¡¡¡ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:Ittakesmorethanhavingtherightmechanisms,standardsandtraininginplacetoensureanopen,ethicalbusinessenvironment.Weworkhardtomakesureweliveuptoourownhighstandards,everyday.LearnmoreWestrivetooperateopenlyandtransparentlyineverythingwedo.Becauseyourtrustinusdependsonit.Weworktoattractandretaindiversesuppliers¨Clargeandsmall¨Cinourmarketsaroundtheworld.Weworkcloselywiththisglobalnetworktoprovidethehighestlevelofservicetoourcustomersandachieveawin-winbusinessrelationship.DescriptionMSDisaninnovative,globalhealthcareleaderthatiscommittedtoimprovinghealthandwell-beingaroundtheworld.Ourcoreproductcategoriesincludediabetes,cancer,vaccinesandhospitalacutecare.Wecontinuetofocusourresearchonconditionsthatrepresentsomeoftoday¡¯smostsignificanthealthchallenges¨Clikecancer,HIV,HPV,hepatitisC,cardio-metabolicdisease,antibiotic-resistantinfectionandAlzheimer'sdisease,andweareonthefrontlinesinthefightagainstemergingglobalpandemics,suchasebola.Wealsodevoteextensivetimeandenergytoincreasingaccesstomedicinesandvaccinesthroughfar-reachingprogramsthatdonateanddeliverourproductstothepeoplewhoneedthem.AtMSD,we'reapplyingourglobalreach,financialstrengthandscientificexcellencetodomoreofwhatwe'repassionateabout:improvinghealthandimprovinglives.

¡¡¡¡Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:

¡¡¡¡DescriptionMSDisaninnovative,globalhealthcareleaderthatiscommittedtoimprovinghealthandwell-beingaroundtheworld.Ourcoreproductcategoriesincludediabetes,cancer,vaccinesandhospitalacutecare.Wecontinuetofocusourresearchonconditionsthatrepresentsomeoftoday¡¯smostsignificanthealthchallenges¨Clikecancer,HIV,HPV,hepatitisC,cardio-metabolicdisease,antibiotic-resistantinfectionandAlzheimer'sdisease,andweareonthefrontlinesinthefightagainstemergingglobalpandemics,suchasebola.Wealsodevoteextensivetimeandenergytoincreasingaccesstomedicinesandvaccinesthroughfar-reachingprogramsthatdonateanddeliverourproductstothepeoplewhoneedthem.AtMSD,we'reapplyingourglobalreach,financialstrengthandscientificexcellencetodomoreofwhatwe'repassionateabout:improvinghealthandimprovinglives.Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.

¡¡¡¡AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.

¡¡¡¡Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:Oursuppliersshouldreflectthepeopleweareinbusinesstoserve...ourcustomers.AtMSD,webelievethathavingadiversesupplierbasehelpsusbetterunderstandandanticipatetheneedsofthepeopleweserve.Thatiswhywecastawidenetinsearchoftalent,seekingqualifiedsuppliersfromallsegmentsoftheglobalcommunity.OursupplierdiversityprogramincludeslargeandsmallHUBZone,minority,women,veteran,andlesbian-andgay-ownedbusinessenterprisesInterestedinbecominganMSDsupplierHere'swhatwe'llexpectfromyou:Weholdoursupplierstothesamestandardstowhichweholdourownemployees.Weexpectoursuppliersto:Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.

¡¡¡¡Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.Inadditiontorespondingtotheneedsofstakeholders,ourcorporateresponsibilityeffortsalsosupportthe,theinternationalcommunity¡¯saspirationsforimprovingthelivesoftheworld¡¯spoorestpeopleby2030.Wehavejoinedgloballeaderstoaddressthegoalsonhealthandwell-being,cleanwater,climatechange,diversityandinclusion,responsibleconsumptionandproductionandothers.OursupportoftheSDGsisatestamenttoourcompany¡¯s125-yearlegacyofinventingforlifetocreateahealthierworldforall.Belowareafewhighlightsfromourrecentlyreleasedcorporateresponsibilityreportthathighlightourcommitmenttoadvancethesocialandeconomicconditionsinthecommunitieswhereweworkandlive:

¡¡¡¡AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..AstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:

¡¡¡¡Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeverydayThereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeveryday

¡¡¡¡Ittakesmorethanhavingtherightmechanisms,standardsandtraininginplacetoensureanopen,ethicalbusinessenvironment.Weworkhardtomakesureweliveuptoourownhighstandards,everyday.LearnmoreWestrivetooperateopenlyandtransparentlyineverythingwedo.Becauseyourtrustinusdependsonit.Weworktoattractandretaindiversesuppliers¨Clargeandsmall¨Cinourmarketsaroundtheworld.Weworkcloselywiththisglobalnetworktoprovidethehighestlevelofservicetoourcustomersandachieveawin-winbusinessrelationship.Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeverydayDescriptionMSDisaninnovative,globalhealthcareleaderthatiscommittedtoimprovinghealthandwell-beingaroundtheworld.Ourcoreproductcategoriesincludediabetes,cancer,vaccinesandhospitalacutecare.Wecontinuetofocusourresearchonconditionsthatrepresentsomeoftoday¡¯smostsignificanthealthchallenges¨Clikecancer,HIV,HPV,hepatitisC,cardio-metabolicdisease,antibiotic-resistantinfectionandAlzheimer'sdisease,andweareonthefrontlinesinthefightagainstemergingglobalpandemics,suchasebola.Wealsodevoteextensivetimeandenergytoincreasingaccesstomedicinesandvaccinesthroughfar-reachingprogramsthatdonateanddeliverourproductstothepeoplewhoneedthem.AtMSD,we'reapplyingourglobalreach,financialstrengthandscientificexcellencetodomoreofwhatwe'repassionateabout:improvinghealthandimprovinglives.

¡¡¡¡ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.

¡¡¡¡Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeverydayInmanycountriesaroundtheworld,suchasCanada,UK,India,Brazil,andChina,ouremployeeshaveusedLIVEITasafoundationforbuildingalocalcultureofwell-being.InCanada,forexample,wedemonstratedimprovementsinbiometrics,fitnessandemotionalhealth,accompaniedbyfewerself-reportedabsences.LIVEIThaslaunchedto53,000employeesin40countries,representingover75percentoftheworkforce.AtMSD,wedefineacultureofwell-beingasadeliberateandresourcedefforttoestablishaworkforceculturethatpromoteshealth,wellnessandsafetyandisfocusedoncreatinghealthydailyhabits.Itembedshealthandsafetyintothedailyfabricoftheworkplace.Werecognizethatasustainablecultureofhealthrequiresstrongleadershipsupport,agrass-rootschampionnetwork(dedicatedandpassionateemployeevolunteers),aworkplaceenvironmentthatsupportshealthfuldecision-makingandastrongandlastingcommitmenttomarketthevalueofbeingwellwithinandacrosstheorganization.Therearemanybenefitstothisapproach.First,thehealthandwell-beingofourworkforcehaveadirectlinktooptimalemployeeperformance.Whetherworkisdoneattheofficeorathome,sickness,injuryandstresscanaffectaperson¡¯sabilitytoperformandcontributeeffectively.Second,thereisincreasingevidencethatahealthyandsafeworkforcecanprovideacompetitiveadvantageinthemarketplace.MSDhasanopportunitytobeanexampleforothercompaniesbysharinglearnings,bestpracticesandevidencethatsupportsthehypothesisthatgoodhealthissmartbusiness.Wealsobelievethataconstructiveapproachtoouremployees'healthandoverallwell-beinghelpstorecruitandretaintopanddiversetalent.Aspiringtoplayaleadershiprole,MSDisleveraginginternalassetsandexternalexpertisetopromotehealthandbuildacorporatecultureofhealth.BecauseatMSDwearetopromoteoptimalhealth,wemustleadbyexample.Wemustbehealthyourselvestodotheimportantworkofsavingandimprovingthelivesofothers.

¡¡¡¡ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeverydayAstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..

¡¡¡¡Inmanycountriesaroundtheworld,suchasCanada,UK,India,Brazil,andChina,ouremployeeshaveusedLIVEITasafoundationforbuildingalocalcultureofwell-being.InCanada,forexample,wedemonstratedimprovementsinbiometrics,fitnessandemotionalhealth,accompaniedbyfewerself-reportedabsences.LIVEIThaslaunchedto53,000employeesin40countries,representingover75percentoftheworkforce.AtMSD,wedefineacultureofwell-beingasadeliberateandresourcedefforttoestablishaworkforceculturethatpromoteshealth,wellnessandsafetyandisfocusedoncreatinghealthydailyhabits.Itembedshealthandsafetyintothedailyfabricoftheworkplace.Werecognizethatasustainablecultureofhealthrequiresstrongleadershipsupport,agrass-rootschampionnetwork(dedicatedandpassionateemployeevolunteers),aworkplaceenvironmentthatsupportshealthfuldecision-makingandastrongandlastingcommitmenttomarketthevalueofbeingwellwithinandacrosstheorganization.Therearemanybenefitstothisapproach.First,thehealthandwell-beingofourworkforcehaveadirectlinktooptimalemployeeperformance.Whetherworkisdoneattheofficeorathome,sickness,injuryandstresscanaffectaperson¡¯sabilitytoperformandcontributeeffectively.Second,thereisincreasingevidencethatahealthyandsafeworkforcecanprovideacompetitiveadvantageinthemarketplace.MSDhasanopportunitytobeanexampleforothercompaniesbysharinglearnings,bestpracticesandevidencethatsupportsthehypothesisthatgoodhealthissmartbusiness.Wealsobelievethataconstructiveapproachtoouremployees'healthandoverallwell-beinghelpstorecruitandretaintopanddiversetalent.Aspiringtoplayaleadershiprole,MSDisleveraginginternalassetsandexternalexpertisetopromotehealthandbuildacorporatecultureofhealth.BecauseatMSDwearetopromoteoptimalhealth,wemustleadbyexample.Wemustbehealthyourselvestodotheimportantworkofsavingandimprovingthelivesofothers.Inmanycountriesaroundtheworld,suchasCanada,UK,India,Brazil,andChina,ouremployeeshaveusedLIVEITasafoundationforbuildingalocalcultureofwell-being.InCanada,forexample,wedemonstratedimprovementsinbiometrics,fitnessandemotionalhealth,accompaniedbyfewerself-reportedabsences.LIVEIThaslaunchedto53,000employeesin40countries,representingover75percentoftheworkforce.AtMSD,wedefineacultureofwell-beingasadeliberateandresourcedefforttoestablishaworkforceculturethatpromoteshealth,wellnessandsafetyandisfocusedoncreatinghealthydailyhabits.Itembedshealthandsafetyintothedailyfabricoftheworkplace.Werecognizethatasustainablecultureofhealthrequiresstrongleadershipsupport,agrass-rootschampionnetwork(dedicatedandpassionateemployeevolunteers),aworkplaceenvironmentthatsupportshealthfuldecision-makingandastrongandlastingcommitmenttomarketthevalueofbeingwellwithinandacrosstheorganization.Therearemanybenefitstothisapproach.First,thehealthandwell-beingofourworkforcehaveadirectlinktooptimalemployeeperformance.Whetherworkisdoneattheofficeorathome,sickness,injuryandstresscanaffectaperson¡¯sabilitytoperformandcontributeeffectively.Second,thereisincreasingevidencethatahealthyandsafeworkforcecanprovideacompetitiveadvantageinthemarketplace.MSDhasanopportunitytobeanexampleforothercompaniesbysharinglearnings,bestpracticesandevidencethatsupportsthehypothesisthatgoodhealthissmartbusiness.Wealsobelievethataconstructiveapproachtoouremployees'healthandoverallwell-beinghelpstorecruitandretaintopanddiversetalent.Aspiringtoplayaleadershiprole,MSDisleveraginginternalassetsandexternalexpertisetopromotehealthandbuildacorporatecultureofhealth.BecauseatMSDwearetopromoteoptimalhealth,wemustleadbyexample.Wemustbehealthyourselvestodotheimportantworkofsavingandimprovingthelivesofothers.ExpandingPatientAccesstoMSD'sInvestigationalMedicinesWhenresultsfromclinicaltrialssuggestthatoneofourinvestigationalmedicinesmayofferbenefitsforpatientsfacinglife-threateningconditions,MSDiscommittedtobringingthatmedicinetothosepatientsasquicklyandequitablyaspossible.Participationinclinicaltrialsshouldbetheprimaryroutebywhichpatientsgetaccesstoinvestigationalmedicinesandcontributetothecollectionofsafetyandefficacydataneededtosupportregulatoryapprovalworldwide.Theseclinicalstudiesareneededtodemonstratethatthemedicinemeetsthestandardsforsafetyandefficacythatgovernmentregulatoryagencieshaveestablishedforgrantingapproval.Gainingregulatoryapprovalforamedicineisthebestwaytobringrapidaccesstothegreatestnumberofpatientswhomaybenefit.Forpatientswithaseriousorlife-threateningdiseasewhoareineligibleorunabletoparticipateinaclinicaltrial,useofanexpandedaccessprogrammaybeanoption.Dependingoncountryregulationsandtheprogramcriteria,accesstoinvestigationalmedicinesmaybeprovidedthroughExpandedAccessPrograms(EAP)(knownascompassionateuseprogramsincertainjurisdictions),orCountry-SpecificAuthorizationtoUsecohorts.DecisionCriteriaforConsideringanEAPThefollowingcriteriamustbemetbeforeMSDwillconsiderestablishinganEAPforaMSDinvestigationalproduct:

¡¡¡¡DescriptionMSDisaninnovative,globalhealthcareleaderthatiscommittedtoimprovinghealthandwell-beingaroundtheworld.Ourcoreproductcategoriesincludediabetes,cancer,vaccinesandhospitalacutecare.Wecontinuetofocusourresearchonconditionsthatrepresentsomeoftoday¡¯smostsignificanthealthchallenges¨Clikecancer,HIV,HPV,hepatitisC,cardio-metabolicdisease,antibiotic-resistantinfectionandAlzheimer'sdisease,andweareonthefrontlinesinthefightagainstemergingglobalpandemics,suchasebola.Wealsodevoteextensivetimeandenergytoincreasingaccesstomedicinesandvaccinesthroughfar-reachingprogramsthatdonateanddeliverourproductstothepeoplewhoneedthem.AtMSD,we'reapplyingourglobalreach,financialstrengthandscientificexcellencetodomoreofwhatwe'repassionateabout:improvinghealthandimprovinglives.Thereisstillagreatdealofworktobedone,butwehavemadetremendousprogressalready.Simplifyinginformationhelpstoincreasetheoddsthatpeopletakingourmedicinesknowhowandwhentotakethem,andthattheyareabletorecognizeandreportpotentialsideeffects.Whenpatientsarearmedwiththisknowledge,wetrulyoptimizethebenefitsofourmedicalinnovation.Wearemakinggreatstridesasacompanyandanindustrytohelpaperson¡¯sabilitytobetterunderstand,acton,andusehealthinformation.Successdependsonouremployees¡¯passionforandsupportofhealthliteracy.Almosttwentyyearsago,IchosetocometoMSDbecauseofthecompany¡¯slegacyofputtingpatientsfirst.Thisworkbuildsuponthattradition,withhealthliteracychampionsinmanypartsoftheworldinnovatingeverydayAstheseniorvicepresidentforGlobalBiologics,TherapeuticProteinsSterileOperations,Ibelievewecanallbecomemorethoughtfulabouthowmuchwaterweuse,andwecansharebestpracticeswithourcolleagues.Becomingbetterstewardsandpracticingsustainablewaterusewillbetterguaranteethatthewaterwillbethereforuswhenweneedit¨Cforourbusinessandforsociety.ManufacturingSupplyChainOurvisionistobethemosttrustedandcompetitivesupplierofpharmaceuticals,animalhealthproducts,vaccinesandbiologicstotheworld¡¯spatientsandcustomers..Ourglobalwaterstrategyaimstoachievesustainablewatermanagementwithinouroperationsandoursupplychain..

¡¡¡¡Ourvaluesandstandardsarethebasisofoursuccess.Theyalwayshavebeen.Theyalwayswillbe.Thepeoplewhouse,recommendorprescribeourproductshaveplacedtheirtrustinus.Nomatterhowstrongourreputation,wemustre-earnthattrusteverydaybypracticingthevaluesandstandardsthathaveguidedthiscompanyformorethan100years.Weworkhardtomakesurethattheintegrityofthiscompanyremainsapriorityforeveryoneofouremployees-everyday,ateverylevelofourcompany.Ourcodeofconduct,whichwepublishforemployeesunderthetitleOurValuesandStandards,helpstomakesurethatouremployeesunderstandwhatisexpectedofthem,andprovidesguidanceonbusinessstandardsandpractices.Thisisjustoneofthemanywaysthatwecontinuallyreinforcethevaluesonwhichthiscompanywasbuilt.Since1891,ourresearchershavehelpedtofindnewwaystotreatandpreventillness¡ªfromthediscoveryofvitaminB1,tothefirstmeaslesvaccine,tocoldremediesandantacids,tothefirststatinstotreathighcholesterol.Ourscientistshavealsohelpeddevelopmanyproductstoimproveanimalhealth,includingvaccinesandantibiotics.Today,asapremierresearch-intensivebiopharmaceuticalcompany,we¡¯refocusedonmakingimportantscientificadvancementswithinhepatitisC,HIV,diabetesandimmuno-oncology.Whileweareproudofourpast,weareenthusiasticaboutthefuture.Weaimtocreateahealthier,brighterfutureforpeoplearoundtheworld.Inmanycountriesaroundtheworld,suchasCanada,UK,India,Brazil,andChina,ouremployeeshaveusedLIVEITasafoundationforbuildingalocalcultureofwell-being.InCanada,forexample,wedemonstratedimprovementsinbiometrics,fitnessandemotionalhealth,accompaniedbyfewerself-reportedabsences.LIVEIThaslaunchedto53,000employeesin40countries,representingover75percentoftheworkforce.AtMSD,wedefineacultureofwell-beingasadeliberateandresourcedefforttoestablishaworkforceculturethatpromoteshealth,wellnessandsafetyandisfocusedoncreatinghealthydailyhabits.Itembedshealthandsafetyintothedailyfabricoftheworkplace.Werecognizethatasustainablecultureofhealthrequiresstrongleadershipsupport,agrass-rootschampionnetwork(dedicatedandpassionateemployeevolunteers),aworkplaceenvironmentthatsupportshealthfuldecision-makingandastrongandlastingcommitmenttomarketthevalueofbeingwellwithinandacrosstheorganization.Therearemanybenefitstothisapproach.First,thehealthandwell-beingofourworkforcehaveadirectlinktooptimalemployeeperformance.Whetherworkisdoneattheofficeorathome,sickness,injuryandstresscanaffectaperson¡¯sabilitytoperformandcontributeeffectively.Second,thereisincreasingevidencethatahealthyandsafeworkforcecanprovideacompetitiveadvantageinthemarketplace.MSDhasanopportunitytobeanexampleforothercompaniesbysharinglearnings,bestpracticesandevidencethatsupportsthehypothesisthatgoodhealthissmartbusiness.Wealsobelievethataconstructiveapproachtoouremployees'healthandoverallwell-beinghelpstorecruitandretaintopanddiversetalent.Aspiringtoplayaleadershiprole,MSDisleveraginginternalassetsandexternalexpertisetopromotehealthandbuildacorporatecultureofhealth.BecauseatMSDwearetopromoteoptimalhealth,wemustleadbyexample.Wemustbehealthyourselvestodotheimportantworkofsavingandimprovingthelivesofothers.

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